Updated guidelines for the prevention and treatment of opportunistic infections (OIs) in children infected with HIV are now available.
Developed by the National Institutes of Health, PIDS and HIVMA, updates to the guidelines include:
- Greater emphasis on the importance of antiretroviral therapy (ART) for prevention and treatment of OIs, especially those OIs for which no specific therapy exists;
- Increased information about diagnosis and management of IRIS;
- Information about managing ART in children with OIs, including potential drug-drug interactions;
- Updated immunization recommendations for HIV-exposed and HIV-infected children, including pneumococcal, human papillomavirus, meningococcal, and rotavirus vaccines;
- Addition of sections on influenza, giardiasis, and isosporiasis;
- Elimination of sections on aspergillosis, bartonellosis, and HHV-6 and HHV-7 infections; and
- Updated recommendations on discontinuation of OI prophylaxis after immune reconstitution in children.